Dr. sc. ing. Oskars Grīgs

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Oskars Grīgs's picture
Laboratory of Bioengineering

Leading Researcher, Member of Scientific Council, Project Manager

    • Education

    2016 - Doctoral degree of engineering sciences in chemical engineering (Dr. sc. ing.), Faculty of Material sciences and applied chemical engineering, Riga Technical University, Latvia 2010 - Masters degree of engineering sciences in chemical engineering (Mg. sc. ing.), Faculty of Material sciences and applied chemical engineering, Riga Technical University, Latvia 2004 - Secondary education, Agenskalna State Gymnasium

    Scientific interests and competence

    Bio-process engineering. Fermentation process modeling and control. Competence in advanced model-based method application in to fed-batch fermentation optimization and control. Characteristic process parameter (biomass/substrate concentration, respiratory quotient etc.) on-line calculation using soft-sensors and data analysis methods.

    The most important projects

    “Scale-up research of the microbiological soil fertilizer and biocontrol agent obtainment in submerged and surface cultivation processes”, project No. 1.1.1.1/19/A/150, ERAF, “Support for applied research”, (2020-2023), principal researcher. „Development of advanced model-based on-line control system for productivity improvement of recombinant and non-recombinant microorganism cultivation processes”, Post-doctoral research grant (ERAF) Nr. 1.1.1.2/VIAA/1/16/186, 2017-2020,  principal researcher. „The influence of magnetic field driven mixing on biotechnological processes“, ERAF project Nr.Nr.1.1.1.1/16/A/144, 01.2017-09.2017., researcher. „High value product obtaining using laboratory and pilot scale photobioreactors“, ERAF project Nr. 2013/0041/2DP/2.1.1.1.0/13/APIA/VIAA/025, 2014-2015, researcher. „Mathematical model development and application for fermentation model predictive control“, VBBKC project Nr. L-KC-11-0005, KC/2.1.2.1.1/10/01/006, 2013-2014, engineer. “Establishment of Latvian interdisciplinary interuniversity scientific group of systems biology” within activity 1.1.1.2. “Attraction of Human Resources to Science” ESF project Nr. 2009/0207/1DP/1.1.1.2.0/09/APIA/VIAA/128, 2010-2013, researcher.

    More information

    2010 - ...  Senior Researcher, Latvian State Institute of Wood Chemistry 2009 - ...  Engineer, JSC "Biotehniskais Centrs" (www.bioreactors.net). 2005 - 2008  Scientifi Assistant, Department of Chemical Engineering (RTU) and Latvian Biomedical Research and Study Centre.

    The most important publications

     Grigs, O.; Bolmanis, E.; Kazaks, A. HBsAg Production in Methanol Controlled P. pastoris GS115 MutS Bioreactor Process. Key Engineering Materials, 2021, 903, p. 40-45. doi: 10.4028/www.scientific.net/KEM.903.40 [Scopus] Dubencovs, K.; Liepins, J.; Suleiko, A.; Suleiko, A.; Vangravs, R.; Kassaliete, J.; Scerbaka, R.; Grigs, O. Optimization of Synthetic Media Composition for Kluyveromyces marxianus Fed-Batch Cultivation. Fermentation, 2021, 7, 62. doi: 10.3390/fermentation7020062 [Scopus, WoSCC] Grigs, O.; Bolmanis, E.; Galvanauskas, V. Application of In-Situ and Soft-Sensors for Estimation of Recombinant P. pastoris GS115 Biomass Concentration: A Case Analysis of HBcAg (Mut+) and HBsAg (MutS) Production Processes under Varying Conditions. Sensors, 2021, 21, 1268, doi: 10.3390/s21041268 [Scopus, WoSCC] Suleiko A., Vanags J., Konuhova M., Dubencovs K., Grigs O. The application of novel magnetically coupled mixer drives in bioreactors of up to 15 m3. Biochemical Engineering Journal, 2020, Volume 154, Issue 15, February 2020, 107464, doi: 10.1016/j.bej.2019.107464 [Scopus] Grigs O., Galvanauskas V., Dubencovs K., Vanags J., Suleiko A., Berzins T., Kunga L. Model predictive feeding rate control in conventional and single-use lab-scale bioreactors: a study on practical application. Chem.Biochem.Eng.Q., 2016, 30:1, 47-60 p., doi: 10.15255/CABEQ.2015.2212 [Scopus, WoSCC] Vanags J., Kunga L., Dubencovs K., Galvanauskas V., Grigs O. Influence of light intensity and temperature on cultivation of microalgae Desmodesmus communis in flasks and laboratory-scale stirred tank photobioreactor. Latvian Journal of Physics and Technical Science, Volume 52, Issue 2, 1 April 2015: 59-70 p., doi: 10.1515/lpts-2015-0012 [Scopus, WoSCC] Galvanauskas, V., Grigs, O., Vanags, J., Dubencovs, K., Stepanova, V. Model-Based Optimization and pO2 Control of Fed-Batch Escherichia Coli and Saccharomyces Cerevisiae Cultivation Processes. Engineering in Life Sciences, 2013, Vol.13, Iss.2, 172.-184.p., doi: 10.1002/elsc.201200012 [Scopus, WoSCC]